Previously there has been a discussion regarding Acronis VMprotect product line, and I can’t say people were happy with this solution:
http://communities.vmware.com/thread/413626
Also, as far as I’m concerned, replication over WAN used to be a challenge with Acronis VMprotect – a variety of customers reported that they could never get it to work; though, it might have been addressed in the recent VMprotect version.
As to my own experience, we’re using Veeam in our environment for both backup and replication task, and quite satisfied with it; works, as expected.
Cheers.